Endocrine Abstracts

Context: The prevalence of reproductive dysfunction among patients with acromegaly (ACRO) and Cushing’s disease (CD) is high enough, and menstrual disturbances are often the first clinical symptoms of the disease. Objective. The purpose of this study was to assess the functioning of the pituitary-ovarian axis by examination of key hormones.Methods and patients: The study included 58 patients of reproductive age, 21 with ACRO, the average age was 36....

Introduction: Prolactinoma is the most commonly occurring hormonally active pituitary tumor. In most cases, dopamine receptor agonists (DA) as a monotherapy are effective. However, approximately 10% of patients with prolactinomas fail to achieve normalization of serum prolactin levels during treatment with DA, which indicates resistance to this group of drugs.Aims: The goal was to study the pharmacokinetics of cabergoline in patients harboring prolactino...

Introduction: Patients with resistant prolactinomas have reduced fertility todue to chronic anovulation and hypoplasia of uterus and ovaries. SERM tamoxifen demonstrates a recovery of menstrual function and ovulation and reverses the hypoplasia of the uterus. The mechanism of its action in case of hyperprolactinemia is not clear yet.Aim: To study the role of kisspeptin in restoration of reproductive function in patients with prolactinomas treated by tamo...

Introduction: Acromegaly impairs the hypothalamic-pituitary-gonadal (HPG) axis and reproductive function that causes amenorrhea and infertility. The mechanism of these disturbances is not clear. Kisspeptin and neurokinin B are very important neuropeptides regulating cyclic LH release from pituitary due to stimulation of GnRH.Aim: The purpose of this study was to assess the role of key reproductive neuropeptides in regulation of menstrual function in pati...

Introduction: Medical therapy with dopamine agonists is the best treatment for prolactinomas of any size or invasiveness and restores ovulatory cycles in 80–90% of patients. Cabergoline currently suggested nearly exclusively rather than other dopamine agonists due to its excellent tolerability and long half-life. That is why the question of safety using of this drug during pregnancy and embryo-fetal development is actual.Aim: The aim of the study is...

Introduction: Numerous literature sources indicate the potential role of hyperprolactinemia in the development of obesity. Prolactin modulates the functional activity of several enzymes and transporters in adipose tissue and islets of Langerhans, potentially influencing fat and glucose metabolism. On the other hand, elevated prolactin level may induce eating disorders due to dysfunction of dopaminergic regulation of the CNS. We present a clinical case of a man with morbid obes...

Introduction: Extremely low levels of vitamin D usually include levels < 4 ng/ml, which is almost the same as undetectable. The risk groups for vitamin D deficiency have been identified, but do they allow such patients to be identified based solely on clinical presentation.Objective: To identify risk factors and their actual clinical determination in patients with 25(OH)D serum levels <4 ng/ml.Materials and methods: The stu...

Prolactinomas are the most common hormone-active pituitary tumors, most common in young women, whose main reason for going to the doctor is menstrual irregularity. At the onset of the disease before puberty in children, there is a delay in sexual development, in girls primary amenorrhea.A 27-year old woman has been observed since 15 years, when hyperprolactinemia was first detected, level of PRL was 10 900 IU/l, and according to MRI pituitary endose...

Experience in complex therapy of selective and non-selective dopamine agonists in women with resistant prolactinomas for recovering of ovulation function.Introduction: Prolactinomas are the most common pituitary adenomas and dopamine agonists (DA) still remain the first choice of treatment. Nevertheless, it does not always exert an adequate effect and endocrinologists face the challenge of resistant prolactinomas more frequently. This problem is very imp...

Introduction: Hyponatriemia is one of severe postoperative water-electrolyte disturbances. This condition is usually caused by syndrome of inappropriate secretion of antidiuretic hormone or cerebral salt-wasting syndrome which require different treatment approaches.Case presentation: A 61-year-old woman was referred to tertiary care center with non-functioning pituitary macroadenoma. The patient had been suffering from headaches for 4 later years and had...